(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-benzodioxol-5-yl)methyl]dihydrofuran-2(3H)-one
Yatein
CAS: 40456-50-6
Molecular Formula: C22H24O7
(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-benzodioxol-5-yl)methyl]dihydrofuran-2(3H)-one - Names and Identifiers
(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-benzodioxol-5-yl)methyl]dihydrofuran-2(3H)-one - Physico-chemical Properties
| Molecular Formula | C22H24O7 |
| Molar Mass | 400.42176 |
| Density | 1.266±0.06 g/cm3(Predicted) |
| Boling Point | 564.9±45.0 °C(Predicted) |
| Appearance | Powder |
| Storage Condition | 2-8℃ |
(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-benzodioxol-5-yl)methyl]dihydrofuran-2(3H)-one - Reference Information
| biological activity | Yatein is A lignin extracted from A. Yatein inhibited the replication of type 1 by Herpes Sinplex Virus (HSV-1) by interrupting the expression of the early gene. |
| Target | HSV-1 |
| Cell Line: | A549 cells, CL1-5 cells A549 cells, CL1-5 cells |
| Concentration: | 1.25 μM , 2.5 μM , 5 μM 5 μM |
| Incubation Time: | 24 hours 6 hours, 12 hours |
| Result: | Induced cell-cycle arrest at G2/M phase in both cell lines. Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation. Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation. |
| Animal Model: | Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection, five times per week, for 42 days |
Last Update：2024-04-09 21:04:16
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Product Name: Yatein Visit Supplier Webpage Request for quotationCAS: 40456-50-6
Tel: +86-400-900-4166
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Mobile: +86-18621343501
QQ: 2881950922
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View History
(3R,4R)-3-(3,4,5-Trimethoxybenzyl)-4-[(1,3-benzodioxol-5-yl)methyl]dihydrofuran-2(3H)-one
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2-[(2-chlorophenyl)-methylsulfonylamino]acetic acid
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